4-Pyrimidinamine, N-[3-(4-methoxyphenyl)-5-isoxazolyl]-2-(4-morpholinyl)-
BO-264
CAS: 2408648-20-2
Molecular Formula: C18H19N5O3
4-Pyrimidinamine, N-[3-(4-methoxyphenyl)-5-isoxazolyl]-2-(4-morpholinyl)- - Names and Identifiers
| Name | BO-264 |
| Synonyms | BO-264 4-Pyrimidinamine, N-[3-(4-methoxyphenyl)-5-isoxazolyl]-2-(4-morpholinyl)- |
| CAS | 2408648-20-2 |
4-Pyrimidinamine, N-[3-(4-methoxyphenyl)-5-isoxazolyl]-2-(4-morpholinyl)- - Physico-chemical Properties
| Molecular Formula | C18H19N5O3 |
| Molar Mass | 353.38 |
| Density | 1.306±0.06 g/cm3(Predicted) |
| Boling Point | 627.9±65.0 °C(Predicted) |
| Solubility | Soluble in DMSO (>25 mg/ml) |
| Appearance | solid |
| Color | Off-white |
| pKa | 6.69±0.10(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
4-Pyrimidinamine, N-[3-(4-methoxyphenyl)-5-isoxazolyl]-2-(4-morpholinyl)- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.83 ml | 14.149 ml | 28.298 ml |
| 5 mM | 0.566 ml | 2.83 ml | 5.66 ml |
| 10 mM | 0.283 ml | 1.415 ml | 2.83 ml |
| 5 mM | 0.057 ml | 0.283 ml | 0.566 ml |
Last Update：2024-01-02 23:10:35
4-Pyrimidinamine, N-[3-(4-methoxyphenyl)-5-isoxazolyl]-2-(4-morpholinyl)- - Reference Information
| biological activity | BO-264 is an effective oral inhibitor transforming acidic coiled-coil 3 (TACC3) with IC50 value of 188 nM and Kd value of 1.5 nM. BO-264 can specifically block the function of FGFR3-TACC3 fusion protein. BO-264 can induce SAC-dependent mitotic arrest, apoptosis and DNA damage with anti-tumor activity. |
| Target | Value |
| FGFR3 () | |
| TACC3 (Cell-free assay) | 1.5 nM(Kd) 188 nM |
Last Update：2024-04-10 22:29:15
![4-Pyrimidinamine, N-[3-(4-methoxyphenyl)-5-isoxazolyl]-2-(4-morpholinyl)-](http://res.chembk.com/assets/str/2d/2/24/2408648-20-2.png)
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Product Name: BO-264 Visit Supplier Webpage Request for quotationCAS: 2408648-20-2
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Spot supply
Product Name: BO-264 Visit Supplier Webpage Request for quotationCAS: 2408648-20-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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